Bookmark Kaumudi Online  Bookmark this site  Editor@Kaumudi  |  Marketing  Print Advt rates  |  Calendar 2018        Go!    
March 23, Friday 2018 8:27 PM       

       HEADLINES: SFI men assaults Kerala Kaumudi photographer                                              Engineering student commits suicide thinking he wouldn’t be able to write exam                                              Smoke from Thrissur-Ernakulam passenger engine: Trains may get delayed                                              CPI national leadership says no need of relationship with K M Mani                                              CNG, LNG to arrive in Thiruvananthapuram                                              Cong to move no-confidence motion against govt                                              Anna Hazare to start indefinite hunger strike Friday                                              RS polls: Voted for BJP, says BSP MLA Anil Singh                                              Enormity & urgency of ecological issues cannot be ignored: Sadguru                                              Dominance of military turns Pak into failing state: Experts                                              Trump removes McMaster as NSA                                              Dalai Lama to cut foreign travel due to age, exhaustion                                              Sparking fear of trade war, Trump imposes USD 60 bn trade tariffs on China                                              Federer unfazed about No.1 ranking quest                                              Yuki Bhambri cruises into Miami Open second round                                              UAE give Afghan, Ireland WC hopes                                              Nepali cricketer Sandeep Lamichhane receives Delhi Daredevils jersey                                              Santhosh Trophy: Kerala pips Manipur 6-0                                              Kaumudi Facebook
       WEIRDNEWS Next Article: When sex robots helped creator spice up his marriage  
       Vampires may have been real people with a blood disorder
         Posted on :17:42:18 Oct 14, 2017
       Last edited on:17:42:18 Oct 14, 2017
         Tags: Vampires may have been real people with a blo

WASHINGTON DC: The folklore of Vampires has been inspiring a lot of horror stories for hundreds of years and continues to be a hit in Hollywood.

But, according to a recent research the blood sucking creatures might not have been otherworldly as everyone think of.

Today, erythropoietic protoporphyria (EPP) remains rare but is better understood as a genetic mutation that affects oxygen in the blood and makes sufferers allergic to the sun.

Porphyrias, a group of eight known blood disorders, affect the body's molecular machinery for making heme, which is a component of the oxygen-transporting protein, hemoglobin.

When hemglobin binds with iron, it gives blood its hallmark red color.

"People with EPP are chronically anemic, which makes them feel very tired and look very pale with increased photosensitivity because they can't come out in the daylight. Even on a cloudy day, there's enough ultraviolet light to cause blistering and disfigurement of the exposed body parts, ears and nose," said Barry Paw MD, PhD, of the Dana-Farber/Boston Children's Cancer and Blood Disorders Center.

Now, Paw and his team of international investigators report a newly discovered genetic mutation that triggers EPP. It illuminates a novel biological mechanism potentially responsible for stories of "vampires" and identifies a potential therapeutic target for treating EPP.

To produce hemoglobin, the body goes through a process called porphyrin synthesis, which mainly occurs in the liver and bone marrow.

Any genetic defects that impact this process can interrupt the body's ability to produce heme; the decreased heme production leads to a buildup of protoporphyrin components.

In the case of EPP, type of protoporphyrin called protoporphrin IX accumulates in the red blood cells, plasma and sometimes the liver.

When protoporphin IX is exposed to light, it produces chemicals that damage surrounding cells. As a result, people with EPP experience swelling, burning and redness of the skin after exposure to sunlight -- even trace amounts of sunlight that pass through window glass.

Some genetic pathways leading to build-up of protoporphyrin IX have already been described, but many cases of EPP remain unexplained. By performing deep gene sequencing on members of a family from Northern France with EPP of a previously unknown genetic signature, Paw's team discovered a novel mutation of the gene CLPX, which plays a role in mitochondrial protein folding.

"This newly-discovered mutation really highlights the complex genetic network that underpins heme metabolism.Loss-of-function mutations in any number of genes that are part of this network can result in devastating, disfiguring disorders," noted Paw, who was co-senior author on the study.

Paw suggests that identifying the various gene mutations that contribute to porphyria could pave the way for future therapies that could correct the faulty genes responsible for these related disorders.

"Although vampires aren't real, there is a real need for innovative therapies to improve the lives of people with porphyrias," concluded Paw.

Next Article: When sex robots helped creator spice up his marriage
UP: Man performs last rites for his pet parrot  
Madhya Pradesh: Dead man came alive  
Delhi college students protest after semen-filled balloons thrown at girls  
Drunk man survives after biting and killing snake  
MLAs fear spirits haunting Rajasthan Assembly, demand 'yagya'  
Couple gets grandchildren via surrogacy  
Divorce petition filed against dog, goat marriage  
TN: Priests suspended for decorating idol in 'salwar kameez'  
80-year-old woman raped in Pune  
Doctor commits suicide after wife denies him non-veg food  
Modern-day Mowgli: Village boy forges bond with gang of monkeys  
263 coins, shaving blades and needles removed from man's stomach in MP  
Man claims sexual stimulation cleared his sinus  
Turns out, women are fussed about face fuzz  
A Mumbai man's love story with his iPhone X  
Mom who beat girl for incorrect Bible verses gets prison  
Bipasha Basu turns down offer to endorse aerated drink!  
Vampires may have been real people with a blood disorder  
When sex robots helped creator spice up his marriage  
Lord Ganesha issued admit card by a Bihar university  
Karnataka: Infants placed on hot coals as part of religious ritual  
Sex robot Samantha breaks down after being molested tech enthusiasts  
Owl feathers may inspire quieter aircraft, turbines  
'Honest' thieves return booty with a piece of advice  
Chhattisgarh: July 1-born girl named 'GST'  
Can there be conspiracy behind the move to shift India-West Indies one-day cricket match from Thiruvananthapuram to Kochi?
No opinion
Home Kerala India World Business Sports Sci&Tech Education Automobile CityNews Movies Environment Letters 
© Copyright keralakaumudi Online 2011  |  Reproduction in whole or in part without written permission is prohibited.
Head Office Address: Kaumudi Buildings, Pettah P.O, Trivandrum - 695024, India.
Online queries talk to Deepu Sasidharan, + 91 98472 38959 or Email deepu[at]
Customer Service -Advertisement Disclaimer Statement   |  Copyright Policy