Bookmark Kaumudi Online  Bookmark this site  Editor@Kaumudi  |  Marketing  Print Advt rates  |  Calendar 2012        Go!    
 
 
December 18, Monday 2017 12:55 AM       

       HEADLINES: Ockhi: Search to spread to coast of Goa                                              Financial aid for Ockhi victims should not be misused                                              UDF team seeks time to meet PM                                              Ockhi: State govt prepares presentation to make Modi understand extent of tragedy                                              Ockhi: Minister says estimates after Christmas; one more dead body found                                              Now, escort companies in Goa demand Aadhar details                                              RK Nagar bypoll: DMK accuses AIADMK of bribing voters                                              Indian Air Force gets two more women fighter pilots                                              Brexit deal proves critics wrong: Theresa May                                              Global terrorist Saeed issues warning to India                                              Eight killed in Quetta church attack                                              Dhawan and spinners power India to ODI series win over Lankans                                              Indian hopes shatter as Sindhu loses Dubai Open title clash                                              Perth Test: Bowlers grind down England before heaven opens up                                              ISL 2017-18: Chennaiyin FC beat Bengaluru FC 2-1                                              Kaumudi Facebook
       WEIRDNEWS Next Article: Kidnapping, forced marriage: Pakistan's Hindu women hope for protection  
       Treatment-resistant 'HIV reservoir' cells identified
 
         Posted on :17:52:03 Apr 18, 2017
   
A A
       Last edited on:17:52:03 Apr 18, 2017
         Tags: Treatment-resistant 'HIV reservoir, cells id
 
NEW YORK: In a first, scientists have identified HIV reservoir cells where the virus can persist despite treatment, a finding that may pave the way for new therapies to effectively treat the disease.
 
HIV cure research to date has focused on clearing the virus from T cells, a type of white blood cell that is an essential part of the immune system, researchers said.
 
They found the virus persists in HIV-infected macrophages - large white blood cells found in tissues throughout the body including the liver, lung, bone marrow and brain.
 
"These results are paradigm changing because they demonstrate that cells other than T cells can serve as a reservoir for HIV," said Jenna Honeycutt of University of North Carolina in the US.
 
Researchers demonstrated the ability of tissue macrophages to support HIV replication in vivo in the total absence of human T cells.
 
However, how macrophages would respond to antiretroviral therapy (ART) and whether macrophages represented a reservoir for HIV after treatment were unknown.
 
Using a humanised myeloid-only mouse (MoM) model devoid of T cells, researchers showed that ART strongly suppresses HIV replication in tissue macrophages.
 
Yet when HIV treatment was interrupted, viral rebound was observed in one third of the animals. This is consistent with the establishment of persistent infection in tissue macrophages, researchers said.
 
"The fact that HIV-infected macrophages can persist means that any possible therapeutic intervention to eradicate HIV might have to target two very different types of cells," Honeycutt said.
 
"This is the first report demonstrating that tissue macrophages can be infected and that they respond to antiretroviral therapy," Honeycutt said.
 
"In addition, we show that productively infected macrophages can persist despite ART; and most importantly, that they can reinitiate and sustain infection upon therapy interruption even in the absence of T cells - the major target of HIV infection," she said.
 
The study was published in the journal Nature Medicine. 
A A
       WEIRDNEWS
Next Article: Kidnapping, forced marriage: Pakistan's Hindu women hope for protection
 
 
WEIRDNEWS HEADLINES
Complaint against Roopesh Peethambaran for criticising ‘Richie’  
Attack at Kunchacko Boban’s shooting set: Two arrested  
Kunchacko Boban’s shooting location attacked  
Lucifer getting ready  
Sacrificed three films for Kochunni: Priya Anand  
Dileep to shed his beard  
No truth in Anushka, Virat wedding rumours: Spokesperson  
'Today' host fired over 'inappropriate sexual behaviour'  
263 coins, shaving blades and needles removed from man's stomach in MP  
Man claims sexual stimulation cleared his sinus  
Turns out, women are fussed about face fuzz  
A Mumbai man's love story with his iPhone X  
Mom who beat girl for incorrect Bible verses gets prison  
Bipasha Basu turns down offer to endorse aerated drink!  
Vampires may have been real people with a blood disorder  
When sex robots helped creator spice up his marriage  
Lord Ganesha issued admit card by a Bihar university  
Karnataka: Infants placed on hot coals as part of religious ritual  
Sex robot Samantha breaks down after being molested tech enthusiasts  
Owl feathers may inspire quieter aircraft, turbines  
'Honest' thieves return booty with a piece of advice  
Chhattisgarh: July 1-born girl named 'GST'  
Playing video games makes you a better university student!  
UP minister's guard carries gun during MRI scan, ruins machine  
Saddam tries to get Aadhar card for Bin Laden  
 
Do you support Adv Aloor's criticism that judges in lower courts lack guts?
Yes
 
No
 
No opinion
 
 
 
Home Kerala India World Business Sports Sci&Tech Education Automobile CityNews Movies Environment Letters 
© Copyright keralakaumudi Online 2011  |  Reproduction in whole or in part without written permission is prohibited.
Head Office Address: Kaumudi Buildings, Pettah P.O, Trivandrum - 695024, India.
Online queries talk to Deepu Sasidharan, + 91 98472 38959 or Email deepu[at]kaumudi.com
Customer Service -Advertisement Disclaimer Statement   |  Copyright Policy